The A47 eastbound was shut after a crash on the Norfolk - Cambridgeshire border.
The main road between Wisbech and King's Lynn was closed between the B198 roundabout at Walton Highway and the Church Road junction at Terrington St John.
National Highways said the incident took place at around 6.20pm today (Tuesday, May 10).
The road has since reopened, although highways officers warned of possible disruption throughout the night due to barrier works.
An earlier National Highways statement read: "Emergency services are currently on scene.
"Traffic is currently being diverted via local roads.
"If this closure impacts on your planned route, please allow extra journey time. Plan ahead, you may wish to re-route or even delay your journey."
For the most up-to-date information about Wisbech's roads, visit our LIVE Wisbech traffic map.
Join our Cambridgeshire Travel Information group on Facebook for all the latest traffic news in Cambridgeshire, or our Norfolk Travel Information group on Facebook for Norfolk.
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